EWSR1

Across TCGA patient cohorts, EWSR1 mutation is significantly associated with the RNA expression of many other genes, with 1,726 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EWSR1-associated genes across cancer lineages are LCEP1, MIR6776, and RNA5SP419. Each is linked with EWSR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EWSR1-to-partner and partner-to-EWSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCEP1 grouped by EWSR1-low versus EWSR1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EWSR1→partner) and Y-score (partner→EWSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LCEP1 →	+0.080	+4.683	<.001	.005	3	3
BRCA	MIR6776 →	+0.788	+5.064	<.001	<.001	3	2
UCEC	RNA5SP419 →	+0.559	+1.977	<.001	.004	3	2
COAD	RNU6-3P →	+0.623	+2.437	<.001	.006	3	2
COAD	SCARNA18 →	+0.696	+3.332	.004	<.001	3	2
COAD	RNU2-60P →	+0.196	+3.187	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,726 associations by consensus.

LCEP1 by EWSR1 expression — BRCA

Explore this box plot interactively →