ETV3L

Across TCGA patient cohorts, ETV3L mutation is significantly associated with the RNA expression of many other genes, with 649 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETV3L-associated genes across cancer lineages are RNU6-684P, GFER, and WRAP53. Each is linked with ETV3L in more than 1 cancer types. Because this analysis shows association rather than direction, both ETV3L-to-partner and partner-to-ETV3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-684P grouped by ETV3L-low versus ETV3L-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV3L→partner) and Y-score (partner→ETV3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-684P →	+0.348	+7.954	<.001	.008	3	2
UCEC	GFER →	+0.453	+2.864	.001	.001	3	2
UCEC	WRAP53 →	+0.497	+2.928	.003	.001	3	2
SKCM	RNA5SP369 →	+0.150	+4.578	<.001	<.001	3	2
LUAD	RNU6-77P →	+1.646	+3.013	<.001	.006	3	2
LUSC	RPL9P13 →	+0.076	+5.081	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 649 associations by consensus.

RNU6-684P by ETV3L expression — HNSC

Explore this box plot interactively →