ETV3L

Across TCGA pan-cancer cohorts, ETV3L RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ETV3L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ETV3L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ETV3L is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, KIRC, and BRCA are the cancer types where ETV3L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ETV3L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.190	.001	10	view →
KIRC	Male	All	+0.039	<.001	7	view →
BRCA	Female	II,III,IV	−0.910	<.001	6	view →
LIHC	All	All	+0.016	.007	4	view →
LUSC	All	All	+0.138	.005	2	view →
CHOL	All	All	+0.062	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ETV3L–HNSC

Open the HNSC breakdown →