ETV3L

Across TCGA patient cohorts, ETV3L mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETV3L-associated genes across cancer lineages are Tuberin, 53BP1, and eEF2. Each is linked with ETV3L in more than 1 cancer types. Because this analysis shows association rather than direction, both ETV3L-to-partner and partner-to-ETV3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by ETV3L-low versus ETV3L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV3L→partner) and Y-score (partner→ETV3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.374	+3.169	.001	.018	3	2
UCEC	53BP1 →	+0.415	+3.169	.005	.018	3	2
UCEC	eEF2 →	+0.342	+2.115	.028	.019	3	1
UCEC	ERK2 →	+0.280	+2.807	<.001	.003	3	1
UCEC	INPP4B →	-0.308	-2.102	.029	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.194	-2.102	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Tuberin by ETV3L expression — UCEC

Explore this box plot interactively →