ETV3

Across TCGA patient cohorts, ETV3 mutation is significantly associated with the RNA expression of many other genes, with 2,086 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETV3-associated genes across cancer lineages are HMGB3P19, RNU2-61P, and RN7SL429P. Each is linked with ETV3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ETV3-to-partner and partner-to-ETV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB3P19 grouped by ETV3-low versus ETV3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV3→partner) and Y-score (partner→ETV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMGB3P19 →	+0.077	+6.324	.009	.001	3	3
COAD	RNU2-61P →	+0.918	+4.666	<.001	.005	3	3
COAD	RN7SL429P →	+0.926	+4.418	<.001	.008	3	3
BRCA	MIR138-1 →	+0.508	+5.175	<.001	.007	3	2
LUAD	MTCO3P17 →	+0.176	+5.076	<.001	.001	3	2
LUAD	SPANXN2 →	+0.197	+6.900	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,086 associations by consensus.

HMGB3P19 by ETV3 expression — BRCA

Explore this box plot interactively →