ETV3

Across TCGA pan-cancer cohorts, ETV3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ETV3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ETV3 RNA is repressed in tumor relative to normal tissue. In most cancer types ETV3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where ETV3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ETV3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.221	<.001	8	view →
LIHC	Female	II,III,IV	+0.904	<.001	8	view →
THCA	All	II,III,IV	−0.620	<.001	8	view →
CHOL	Male	All	+2.231	<.001	5	view →
HNSC	All	All	+0.497	.001	5	view →
LUAD	All	II,III,IV	−0.352	.008	4	view →
COAD	Male	All	+0.286	.016	3	view →
KIRP	Male	All	−0.339	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ETV3–KICH

Open the KICH breakdown →