ETV3

Across TCGA cell cohorts, ETV3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ETV3-associated genes across cancer lineages are SLC38A8, KRTAP10-3, and KRTAP10-5. Each is linked with ETV3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETV3-to-partner and partner-to-ETV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC38A8 grouped by ETV3-low versus ETV3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV3→partner) and Y-score (partner→ETV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC38A8 →	+0.057	+4.191	.006	.007	3	1
BLOOD_Lymphoma	KRTAP10-3 →	+0.027	+4.643	<.001	.005	3	1
STOMACH	KRTAP10-5 →	+0.036	+5.285	<.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.144	+4.155	<.001	.003	3	1
BLOOD_Leukemia	IRX4 →	+0.228	+4.469	<.001	.001	3	1
BLOOD_Leukemia	DPT →	+1.493	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SLC38A8 by ETV3 expression — BLOOD_Lymphoma

Explore this box plot interactively →