ETNPPL

Across TCGA cell cohorts, ETNPPL mutation is significantly associated with the drug of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ETNPPL-associated genes across cancer lineages are GSK2801, Dihydrorotenone, and OF-1. Each is linked with ETNPPL in more than 1 cancer types. Because this analysis shows association rather than direction, both ETNPPL-to-partner and partner-to-ETNPPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK2801 grouped by ETNPPL-low versus ETNPPL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETNPPL→partner) and Y-score (partner→ETNPPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK2801 →	+0.329	+2.649	.038	.046	3	1
LARGE_INTESTINE	Dihydrorotenone →	+0.498	+2.649	.014	.046	3	1
LARGE_INTESTINE	OF-1 →	+0.285	+2.868	.038	.022	2	1
LARGE_INTESTINE	PD0325901 →	-0.754	-2.745	.002	.047	1	1
LARGE_INTESTINE	SCH772984 →	-0.698	-2.745	.006	.047	1	1
LARGE_INTESTINE	AZD5991 →	+0.873	+2.649	.022	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GSK2801 by ETNPPL expression — LARGE_INTESTINE

Explore this box plot interactively →