ETNPPL

Across TCGA pan-cancer cohorts, ETNPPL RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ETNPPL’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ETNPPL RNA is repressed in tumor relative to normal tissue. In most cancer types ETNPPL is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and STAD are the cancer types where ETNPPL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ETNPPL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−2.413	<.001	11	view →
KIRP	All	III,IV	−1.659	<.001	10	view →
STAD	All	II,III,IV	−0.798	.006	7	view →
KICH	Female	All	−1.516	<.001	6	view →
KIRC	Male	All	−1.049	<.001	6	view →
HNSC	All	All	−0.380	.007	6	view →
CHOL	Female	All	−5.346	<.001	5	view →
LUAD	All	All	+0.322	.004	3	view →
BLCA	All	All	−0.196	.047	2	view →
ESCA	All	All	−2.363	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ETNPPL–THCA

Open the THCA breakdown →