ETNPPL

Across TCGA pan-cancer cohorts, ETNPPL RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ETNPPL data layer compared with 4 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ETNPPL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ETNPPL expression acts as an unfavorable survival marker, although some lineages such as KIRP and BRCA show a favorable association.

UVM, KIRP, and BRCA are the cancer types where ETNPPL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.377	0.786	<.001	112	view →
KIRP	DFS	Tertile	All	0.941	0.444	<.001	108	view →
BRCA	OS	Tertile	II,III,IV	0.978	0.928	<.001	105	view →
KICH	DFS	Tertile	All	0.456	0.958	<.001	99	view →
MESO	OS	Tertile	All	0.746	0.404	<.001	79	view →
LGG	DFS	Median	All	0.816	0.660	<.001	48	view →
HNSC	OS	Median	III,IV	0.203	0.410	.004	48	view →
LUSC	OS	Quartile	III,IV	0.466	0.766	.003	31	view →
COAD	OS	Tertile	All	0.386	0.600	.008	24	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	18	view →
KIRC	DFS	Quartile	IV	0.768	0.475	.010	16	view →
LUAD	DFS	Tertile	All	0.730	0.820	.015	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ETNPPL–UVM (OS)

Open the UVM breakdown →