ETF1

Across TCGA patient cohorts, ETF1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETF1-associated genes across cancer lineages are ATM, EGFR_pY1068, and eIF4G. Each is linked with ETF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETF1-to-partner and partner-to-ETF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ETF1-low versus ETF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETF1→partner) and Y-score (partner→ETF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.357	-2.308	.032	.033	3	2
UCEC	EGFR_pY1068 →	-0.182	-2.115	.048	.017	3	1
UCEC	eIF4G →	+0.236	+1.502	.038	.030	3	1
UCEC	Gab2 →	+0.335	+1.502	.010	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.172	-2.807	.005	.003	3	1
UCEC	JNK2 →	+0.186	+1.502	.011	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by ETF1 expression — UCEC

Explore this box plot interactively →