ETDA

Across TCGA patient cohorts, ETDA mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETDA-associated genes across cancer lineages are RNU6-1155P, CCL27, and LINC02337. Each is linked with ETDA in more than 1 cancer types. Because this analysis shows association rather than direction, both ETDA-to-partner and partner-to-ETDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1155P grouped by ETDA-low versus ETDA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETDA→partner) and Y-score (partner→ETDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1155P →	+0.451	+7.060	<.001	<.001	3	1
UCEC	CCL27 →	+0.113	+6.470	<.001	<.001	3	1
UCEC	LINC02337 →	+0.386	+4.621	<.001	.008	3	1
UCEC	RN7SKP172 →	+0.159	+4.551	.005	.009	3	1
UCEC	NDUFS5P5 →	+0.481	+4.326	<.001	.007	3	1
UCEC	RNU6-718P →	+0.447	+5.877	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

RNU6-1155P by ETDA expression — UCEC

Explore this box plot interactively →