ETDA

Across TCGA pan-cancer cohorts, ETDA RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated ETDA data layer.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher ETDA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ETDA expression acts as an unfavorable survival marker, although some lineages such as MESO and UCS show a favorable association.

TGCT, DLBC, and LIHC are the cancer types where ETDA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	OS	Tertile	III,IV	0.003	1.000	<.001	72	view →
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	45	view →
LIHC	OS	Tertile	II,III,IV	0.285	0.643	<.001	45	view →
MESO	OS	Tertile	All	0.734	0.472	.002	42	view →
BLCA	DFS	Tertile	III,IV	0.212	0.515	.002	27	view →
COAD	DFS	Tertile	II,III,IV	0.502	0.679	.007	27	view →
LUAD	OS	Median	IV	0.279	0.730	.012	25	view →
KIRP	DFS	Tertile	IV	0.088	0.511	.002	18	view →
UCS	DFS	Tertile	IV	0.996	0.522	.015	18	view →
PCPG	DFS	Tertile	All	0.664	0.891	.012	15	view →
KIRC	OS	Quartile	All	0.448	0.669	.005	14	view →
BRCA	DFS	Quartile	IV	0.657	0.200	.021	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

ETDA–TGCT (OS)

Open the TGCT breakdown →