ESX1

Across TCGA patient cohorts, ESX1 mutation is significantly associated with the RNA expression of many other genes, with 5,104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESX1-associated genes across cancer lineages are ZC3H14, PSMC1, and ATP6V1G1P4. Each is linked with ESX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESX1-to-partner and partner-to-ESX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZC3H14 grouped by ESX1-low versus ESX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESX1→partner) and Y-score (partner→ESX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZC3H14 →	+0.446	+3.850	<.001	<.001	3	3
UCEC	PSMC1 →	+0.559	+2.584	<.001	<.001	3	3
SKCM	ATP6V1G1P4 →	+0.153	+3.353	.004	.003	3	3
LUAD	RPL23AP45 →	+0.065	+3.473	<.001	.006	3	3
UCEC	RABEP1 →	+0.467	+2.928	<.001	<.001	3	3
UCS	MTND3P5 →	+0.240	+5.700	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,104 associations by consensus.

ZC3H14 by ESX1 expression — UCEC

Explore this box plot interactively →