ESPL1

Across TCGA patient cohorts, ESPL1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESPL1-associated genes across cancer lineages are Notch1, Rab25, and Rad50. Each is linked with ESPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESPL1-to-partner and partner-to-ESPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ESPL1-low versus ESPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPL1→partner) and Y-score (partner→ESPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.148	+1.527	<.001	.007	3	3
UCEC	Rab25 →	-0.248	-1.054	.008	.029	3	3
COAD	Rad50 →	-0.285	-1.691	.001	.043	3	3
UCEC	C-Raf →	+0.112	+1.415	.005	.040	3	3
STAD	Rab11 →	-0.186	-3.169	.028	.019	3	2
COAD	DJ-1 →	+0.213	+2.230	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Notch1 by ESPL1 expression — UCEC

Explore this box plot interactively →