ESPL1

Across TCGA pan-cancer cohorts, ESPL1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ESPL1 data layer compared with 11 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ESPL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ESPL1 expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

ACC, KIRP, and KICH are the cancer types where ESPL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.393	0.822	<.001	166	view →
KIRP	OS	Tertile	All	0.472	0.809	<.001	128	view →
KICH	DFS	Quartile	II,III,IV	0.447	1.000	<.001	103	view →
MESO	OS	Median	All	0.246	0.520	<.001	102	view →
LIHC	DFS	Median	All	0.461	0.622	<.001	82	view →
KIRC	DFS	Tertile	All	0.729	0.879	<.001	73	view →
LGG	OS	Median	All	0.713	0.904	<.001	54	view →
UVM	DFS	Quartile	All	0.367	0.832	<.001	51	view →
LUAD	OS	Median	All	0.611	0.754	<.001	47	view →
SKCM	OS	Median	All	0.277	0.411	<.001	40	view →
UCEC	DFS	Median	All	0.558	0.720	<.001	40	view →
SARC	DFS	Median	All	0.414	0.613	<.001	38	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ESPL1–ACC (OS)

Open the ACC breakdown →