ESPL1

Across TCGA pan-cancer cohorts, ESPL1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ESPL1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ESPL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ESPL1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, LUAD, and UCEC are the cancer types where ESPL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ESPL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.512	<.001	11	view →
LUAD	Male	III,IV	+2.161	<.001	9	view →
UCEC	All	III,IV	+3.315	<.001	8	view →
LUSC	Male	II,III,IV	+2.962	<.001	8	view →
BLCA	Male	III,IV	+2.661	<.001	8	view →
LIHC	Male	All	+1.138	<.001	8	view →
KIRC	Male	IV	+0.827	<.001	8	view →
STAD	All	All	+1.268	.003	7	view →
BRCA	All	III,IV	+1.927	<.001	6	view →
THCA	All	III,IV	+0.346	<.001	6	view →
CHOL	Male	All	+2.489	<.001	4	view →
READ	All	All	+1.301	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ESPL1–COAD

Open the COAD breakdown →