ESPL1

Across TCGA cell cohorts, ESPL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,639 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ESPL1-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Mitotic nuclear division, and Positive regulation of mitotic sister chromatid separation. Each is linked with ESPL1 in more than 19 cancer types. Because this analysis shows association rather than direction, both ESPL1-to-partner and partner-to-ESPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by ESPL1-low versus ESPL1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPL1→partner) and Y-score (partner→ESPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of cell cycle process →	+0.077	+1.549	.002	<.001	3	20
STOMACH	Mitotic nuclear division →	+0.126	+1.348	<.001	<.001	3	20
SOFT_TISSUE	Positive regulation of mitotic sister chromatid separation →	+0.186	+1.597	<.001	<.001	3	20
BONE	Mitotic spindle elongation →	+0.274	+1.500	.002	.001	3	20
STOMACH	Positive regulation of cell cycle →	+0.081	+1.466	<.001	<.001	3	20
STOMACH	Negative regulation of sister chromatid cohesion →	+0.160	+1.295	.001	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,639 associations by consensus.

Negative regulation of cell cycle process by ESPL1 expression — BONE

Explore this box plot interactively →