ESPL1

Across TCGA cell cohorts, ESPL1 mutation is significantly associated with the RNA expression of many other genes, with 1,887 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESPL1-associated genes across cancer lineages are CCDC138, GRK3, and CBY1. Each is linked with ESPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESPL1-to-partner and partner-to-ESPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC138 grouped by ESPL1-low versus ESPL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPL1→partner) and Y-score (partner→ESPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC138 →	+0.695	+2.380	.002	.008	3	3
LARGE_INTESTINE	GRK3 →	+0.885	+2.714	<.001	.002	3	2
LARGE_INTESTINE	CBY1 →	+0.586	+3.307	<.001	.003	3	2
BLOOD_Leukemia	ZMYND8 →	-0.760	-3.539	<.001	.001	3	2
LARGE_INTESTINE	PIAS4 →	+0.738	+2.628	<.001	.002	2	3
LARGE_INTESTINE	RIC8B →	+0.537	+3.459	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,887 associations by consensus.

CCDC138 by ESPL1 expression — BLOOD_Leukemia

Explore this box plot interactively →