ESF1

Across TCGA cell cohorts, ESF1 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ESF1-associated genes across cancer lineages are KRTAP5-4, OR9A2, and VN1R2. Each is linked with ESF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESF1-to-partner and partner-to-ESF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-4 grouped by ESF1-low versus ESF1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESF1→partner) and Y-score (partner→ESF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRTAP5-4 →	+0.087	+2.276	.002	.007	3	2
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	VN1R2 →	+0.006	+5.643	.003	.002	3	1
BLOOD_Lymphoma	OR14A16 →	+0.023	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OR6C68 →	+0.068	+5.209	<.001	.005	3	1
LUNG_SCLC	H4C12 →	+0.602	+4.523	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

KRTAP5-4 by ESF1 expression — BREAST

Explore this box plot interactively →