ESD

Across TCGA patient cohorts, ESD mutation is significantly associated with the RNA expression of many other genes, with 2,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESD-associated genes across cancer lineages are RNU6-278P, USP9YP2, and IFNWP4. Each is linked with ESD in more than 1 cancer types. Because this analysis shows association rather than direction, both ESD-to-partner and partner-to-ESD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-278P grouped by ESD-low versus ESD-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESD→partner) and Y-score (partner→ESD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-278P →	+0.272	+7.731	<.001	.009	3	2
BRCA	USP9YP2 →	+0.044	+7.731	<.001	.009	3	2
HNSC	IFNWP4 →	+0.161	+6.221	<.001	.001	3	2
UCEC	F2 →	+0.511	+2.680	.009	.005	3	2
UCEC	FCF1P6 →	+0.146	+2.298	.009	<.001	3	2
UCEC	RN7SKP98 →	+0.227	+1.893	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,136 associations by consensus.

RNU6-278P by ESD expression — BRCA

Explore this box plot interactively →