ESD

Across TCGA pan-cancer cohorts, ESD RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ESD’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ESD RNA is repressed in tumor relative to normal tissue. In most cancer types ESD is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, KIRC, and HNSC are the cancer types where ESD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ESD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−0.913	<.001	11	view →
KIRC	Female	All	+0.504	<.001	11	view →
HNSC	All	IV	+0.575	<.001	10	view →
UCEC	All	All	−1.421	<.001	8	view →
BLCA	Male	All	−0.849	<.001	8	view →
LUAD	All	II,III,IV	−0.386	<.001	8	view →
LUSC	All	All	−0.298	<.001	7	view →
KICH	Female	II,III,IV	−1.511	<.001	6	view →
BRCA	All	All	−0.621	<.001	6	view →
ESCA	All	All	+0.748	.003	2	view →
CHOL	All	II,III,IV	+0.740	.049	2	view →
PRAD	All	All	−0.379	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ESD–THCA

Open the THCA breakdown →