ESD

Across TCGA pan-cancer cohorts, ESD RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ESD data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ESD RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ESD expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

HNSC, BLCA, and KIRC are the cancer types where ESD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.642	0.747	<.001	152	view →
BLCA	OS	Quartile	All	0.313	0.595	<.001	137	view →
KIRC	OS	Median	All	0.746	0.502	<.001	126	view →
CESC	DFS	Tertile	All	0.395	0.650	.001	84	view →
ACC	DFS	Tertile	All	0.231	0.821	<.001	36	view →
KIRP	DFS	Median	All	0.901	0.605	.003	34	view →
THCA	DFS	Tertile	All	0.898	0.765	.003	33	view →
ESCA	OS	Median	III,IV	0.320	0.546	.011	26	view →
MESO	OS	Median	III,IV	0.490	0.287	.005	23	view →
LUAD	OS	Median	III,IV	0.299	0.644	.001	19	view →
UCS	DFS	Median	II,III,IV	0.618	0.283	.006	14	view →
KICH	DFS	Median	II,III,IV	0.583	0.920	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ESD–HNSC (DFS)

Open the HNSC breakdown →