ESD

Across TCGA patient cohorts, ESD mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESD-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and INPP4B. Each is linked with ESD in more than 1 cancer types. Because this analysis shows association rather than direction, both ESD-to-partner and partner-to-ESD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ESD-low versus ESD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESD→partner) and Y-score (partner→ESD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.171	-3.000	.002	.036	3	1
UCEC	FoxM1 →	+0.365	+3.700	.002	.001	3	1
UCEC	INPP4B →	-0.346	-3.169	.021	.018	3	1
UCEC	MEK1 →	+0.372	+2.321	.029	.034	3	1
UCEC	mTOR_pS2448 →	-0.186	-2.986	.007	.035	3	1
UCEC	Src_pY527 →	-0.410	-2.990	.041	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

A-Raf_pS299 by ESD expression — UCEC

Explore this box plot interactively →