ERVW-1

Across TCGA patient cohorts, ERVW-1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,798 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ERVW-1-associated proteins across cancer lineages are PRUNE1_S399, DDX21_S89, and NFIX. Each is linked with ERVW-1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ERVW-1-to-partner and partner-to-ERVW-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERVW-1 versus PRUNE1_S399 in PDAC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVW-1→partner) and Y-score (partner→ERVW-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PRUNE1_S399 →	+0.963	+0.366	.001	.001	3	4
HNSC	DDX21_S89 →	-0.872	-0.648	<.001	<.001	3	4
HNSC	NFIX →	+0.530	+0.746	<.001	<.001	3	4
LUAD	NOP14_S96 →	-0.699	-0.430	<.001	<.001	3	4
HNSC	NR2F2 →	+0.457	+0.716	<.001	<.001	3	4
LUAD	TTI1 →	-0.217	-0.302	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,798 associations by consensus.

ERVW-1 vs PRUNE1_S399 — PDAC

Explore this scatter interactively →