ERVW-1

Across TCGA pan-cancer cohorts, ERVW-1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ERVW-1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ERVW-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ERVW-1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where ERVW-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERVW-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.087	<.001	8	view →
THCA	Female	II,III,IV	−0.207	<.001	6	view →
LIHC	All	All	+0.014	.001	5	view →
KICH	All	All	−0.059	.001	3	view →
LUAD	Female	II,III,IV	−0.180	.006	2	view →
CHOL	All	All	+0.071	.011	2	view →
READ	All	III,IV	−0.065	.028	2	view →
STAD	Male	All	+0.108	.035	1	view →
COAD	All	All	+0.048	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ERVW-1–KIRC

Open the KIRC breakdown →