ERVW-1

Across TCGA pan-cancer cohorts, ERVW-1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ERVW-1 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ERVW-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ERVW-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, UVM, and KIRC are the cancer types where ERVW-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.493	0.262	<.001	103	view →
UVM	DFS	Median	III,IV	0.233	0.789	<.001	69	view →
KIRC	DFS	Tertile	III,IV	0.668	0.319	<.001	67	view →
MESO	DFS	Median	II,III,IV	0.279	0.458	.003	51	view →
BLCA	DFS	Tertile	II,III,IV	0.253	0.436	.002	24	view →
UCS	OS	Median	IV	0.752	0.404	.013	20	view →
SKCM	DFS	Quartile	All	0.321	0.181	.003	16	view →
THYM	DFS	Median	III,IV	1.000	0.480	.010	15	view →
KIRP	DFS	Tertile	All	1.000	0.825	.011	14	view →
UCEC	OS	Median	All	0.572	0.780	.005	14	view →
BRCA	DFS	Median	III,IV	0.920	0.835	.008	12	view →
READ	DFS	Median	IV	0.353	0.794	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ERVW-1–HNSC (OS)

Open the HNSC breakdown →