ERVW-1

Across TCGA patient cohorts, ERVW-1 mutation is significantly associated with the RNA expression of many other genes, with 1,621 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVW-1-associated genes across cancer lineages are RNU6-910P, RNU6-77P, and NEURL1-AS1. Each is linked with ERVW-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVW-1-to-partner and partner-to-ERVW-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-910P grouped by ERVW-1-low versus ERVW-1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVW-1→partner) and Y-score (partner→ERVW-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-910P →	+0.274	+4.798	<.001	.006	3	2
LUAD	RNU6-77P →	+1.848	+4.598	<.001	.004	3	2
LUAD	NEURL1-AS1 →	+0.097	+5.116	.001	.001	3	2
SKCM	LINC02509 →	+0.215	+4.328	<.001	.007	3	2
SKCM	RARRES2P5 →	+0.145	+3.915	.001	.002	3	2
SKCM	RN7SL246P →	+0.152	+4.050	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,621 associations by consensus.

RNU6-910P by ERVW-1 expression — LUAD

Explore this box plot interactively →