ERVW-1

Across TCGA patient cohorts, ERVW-1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVW-1-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and p70-S6K_pT389. Each is linked with ERVW-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVW-1-to-partner and partner-to-ERVW-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ERVW-1-low versus ERVW-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVW-1→partner) and Y-score (partner→ERVW-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.160	+1.765	.043	.014	3	2
UCEC	JNK_pT183_Y185 →	-0.187	-1.752	.003	.014	3	2
UCEC	p70-S6K_pT389 →	-0.167	-2.584	.019	.010	3	2
UCEC	Cyclin-B1 →	+0.433	+1.415	.040	.046	3	2
UCEC	14-3-3_beta →	-0.094	-2.432	.012	.018	3	1
UCEC	ERK2 →	+0.149	+1.765	.038	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by ERVW-1 expression — UCEC

Explore this box plot interactively →