ERVW-1

Across TCGA cell cohorts, ERVW-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,076 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ERVW-1-associated GO terms across cancer lineages are Negative regulation of translational initiation, Regulation of translational initiation, and Pre-mRNA catabolic process. Each is linked with ERVW-1 in more than 14 cancer types. Because this analysis shows association rather than direction, both ERVW-1-to-partner and partner-to-ERVW-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of translational initiation grouped by ERVW-1-low versus ERVW-1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVW-1→partner) and Y-score (partner→ERVW-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of translational initiation →	+0.077	+2.230	<.001	.005	3	15
OESOPHAGUS	Regulation of translational initiation →	+0.109	+0.236	.001	.006	3	15
BLOOD_Lymphoma	Pre-mRNA catabolic process →	+0.168	+0.513	<.001	<.001	3	15
BONE	Late viral transcription →	+0.162	+0.261	<.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.101	+0.275	<.001	<.001	3	14
SOFT_TISSUE	Negative regulation of mRNA metabolic process →	+0.079	+3.163	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,076 associations by consensus.

Negative regulation of translational initiation by ERVW-1 expression — SOFT_TISSUE

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