ERVW-1

Across TCGA cell cohorts, ERVW-1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ERVW-1-associated genes across cancer lineages are ECRG4, REG3A, and TSBP1. Each is linked with ERVW-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVW-1-to-partner and partner-to-ERVW-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECRG4 grouped by ERVW-1-low versus ERVW-1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVW-1→partner) and Y-score (partner→ERVW-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ECRG4 →	+0.062	+3.188	<.001	.004	3	2
LUNG_SCLC	REG3A →	+0.044	+4.058	<.001	.007	3	1
LUNG_SCLC	TSBP1 →	+0.040	+3.898	.005	.005	3	1
LARGE_INTESTINE	SOX3 →	+0.037	+3.793	.009	.007	3	1
SKIN	CDR1 →	+0.226	+3.920	<.001	.005	3	1
LUNG_NSCLC_LUAD	TAS2R8 →	+0.049	+3.879	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ECRG4 by ERVW-1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →