ERVV-2

Across TCGA patient cohorts, ERVV-2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,584 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ERVV-2-associated GO terms across cancer lineages are Regulation of cell cycle G2/M phase transition, Regulation of nucleotide metabolic process, and Regulation of cyclin-dependent protein kinase activity. Each is linked with ERVV-2 in more than 10 cancer types. Because this analysis shows association rather than direction, both ERVV-2-to-partner and partner-to-ERVV-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell cycle G2/M phase transition grouped by ERVV-2-low versus ERVV-2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVV-2→partner) and Y-score (partner→ERVV-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of cell cycle G2/M phase transition →	+0.066	+0.301	<.001	<.001	3	11
ESCA	Regulation of nucleotide metabolic process →	+0.053	+0.292	<.001	<.001	3	11
STAD	Regulation of cyclin-dependent protein kinase activity →	+0.060	+0.350	<.001	<.001	3	10
LIHC	Regulation of metaphase plate congression →	+0.060	+0.099	<.001	<.001	3	10
STAD	Cytokinetic process →	+0.066	+0.269	<.001	<.001	3	10
STAD	Glycolipid transport →	+0.044	+0.212	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,584 associations by consensus.

Regulation of cell cycle G2/M phase transition by ERVV-2 expression — STAD

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