ERVV-2

Across TCGA pan-cancer cohorts, ERVV-2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ERVV-2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ERVV-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERVV-2 expression acts as an unfavorable survival marker, although some lineages such as OV and KIRP show a favorable association.

KIRC, UCEC, and LIHC are the cancer types where ERVV-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.489	0.724	<.001	170	view →
UCEC	DFS	Median	All	0.787	0.883	<.001	106	view →
LIHC	OS	Tertile	All	0.546	0.723	<.001	55	view →
BLCA	DFS	Median	All	0.263	0.437	.003	46	view →
OV	OS	Quartile	IV	0.539	0.265	.011	28	view →
LGG	OS	Tertile	All	0.802	0.906	.001	27	view →
UCS	DFS	Quartile	III,IV	0.291	0.614	.007	22	view →
KICH	OS	Tertile	All	0.765	0.954	.010	21	view →
KIRP	DFS	Quartile	III,IV	0.857	0.189	.006	21	view →
LUSC	DFS	Median	All	0.671	0.795	<.001	19	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
BRCA	OS	Quartile	All	0.891	0.939	.015	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ERVV-2–KIRC (DFS)

Open the KIRC breakdown →