ERVV-2

Across TCGA pan-cancer cohorts, ERVV-2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ERVV-2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ERVV-2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ERVV-2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BRCA, and LUAD are the cancer types where ERVV-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERVV-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.132	<.001	11	view →
BRCA	Female	II,III,IV	+0.286	<.001	6	view →
LUAD	All	All	+0.188	.001	6	view →
KICH	All	II,III,IV	−0.244	.001	5	view →
COAD	All	All	+0.079	.004	5	view →
KIRP	All	II,III,IV	+1.159	.029	4	view →
BLCA	All	IV	+1.022	.009	4	view →
LIHC	All	All	+0.091	.006	3	view →
UCEC	All	All	+0.249	.018	2	view →
LUSC	Female	All	+0.089	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ERVV-2–HNSC

Open the HNSC breakdown →