ERVV-2

Across TCGA cell cohorts, ERVV-2 mutation is significantly associated with the mutation status of many other genes, with 105 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERVV-2-associated genes across cancer lineages are OR11H12, NFYC, and LRFN3. Each is linked with ERVV-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVV-2-to-partner and partner-to-ERVV-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H12 grouped by ERVV-2-low versus ERVV-2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVV-2→partner) and Y-score (partner→ERVV-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR11H12 →	+5.523	+5.523	.003	.003	1	2
LARGE_INTESTINE	NFYC →	+4.523	+5.087	.006	.006	1	2
OVARY	LRFN3 →	+4.217	+4.217	.001	.001	1	2
LARGE_INTESTINE	PFDN4 →	+5.523	+5.523	.003	.003	1	2
LARGE_INTESTINE	PDCL3 →	+5.523	+5.523	.003	.003	1	2
LARGE_INTESTINE	PAFAH1B3 →	+5.523	+5.523	.003	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

OR11H12 by ERVV-2 expression — LARGE_INTESTINE

Explore this box plot interactively →