ERVV-1

Across TCGA patient cohorts, ERVV-1 mutation is significantly associated with the RNA expression of many other genes, with 3,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVV-1-associated genes across cancer lineages are MIR8053, RNA5SP420, and NDUFAF2P1. Each is linked with ERVV-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVV-1-to-partner and partner-to-ERVV-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by ERVV-1-low versus ERVV-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVV-1→partner) and Y-score (partner→ERVV-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR8053 →	+0.163	+2.919	.002	.007	3	2
UCEC	RNA5SP420 →	+0.537	+1.867	<.001	.007	3	2
UCEC	NDUFAF2P1 →	+0.913	+2.673	<.001	<.001	3	1
UCEC	AQP7P3 →	+0.024	+2.919	<.001	.007	3	1
UCEC	ARRDC3-AS1 →	+0.287	+3.774	<.001	<.001	3	1
UCEC	ABALON →	+0.464	+2.158	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,212 associations by consensus.

MIR8053 by ERVV-1 expression — UCEC

Explore this box plot interactively →