ERVV-1

Across TCGA pan-cancer cohorts, ERVV-1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ERVV-1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ERVV-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ERVV-1 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where ERVV-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERVV-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.240	<.001	8	view →
KIRC	All	II,III,IV	+0.522	.005	7	view →
LUAD	All	All	+0.271	<.001	7	view →
KICH	Female	All	−0.280	<.001	6	view →
COAD	All	All	+0.084	.007	6	view →
BRCA	Female	II,III,IV	+0.238	<.001	4	view →
PRAD	All	All	−0.329	<.001	2	view →
LUSC	All	All	+0.310	.004	2	view →
UCEC	All	IV	+0.135	.032	2	view →
PAAD	Male	All	−0.065	.049	2	view →
ESCA	Female	All	+0.123	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ERVV-1–HNSC

Open the HNSC breakdown →