ERVV-1

Across TCGA pan-cancer cohorts, ERVV-1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated ERVV-1 data layer compared with 1 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ERVV-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ERVV-1 expression acts as an unfavorable survival marker, although some lineages such as ACC and READ show a favorable association.

BRCA, UCEC, and LGG are the cancer types where ERVV-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.896	0.949	<.001	59	view →
UCEC	DFS	Quartile	All	0.621	0.765	.001	42	view →
LGG	OS	Tertile	All	0.707	0.840	<.001	38	view →
KIRC	DFS	Median	All	0.488	0.741	<.001	28	view →
ACC	OS	Tertile	III,IV	0.789	0.316	.027	21	view →
READ	OS	Tertile	III,IV	0.895	0.645	.010	19	view →
LUSC	DFS	Tertile	All	0.269	0.438	<.001	19	view →
LUAD	DFS	Quartile	II,III,IV	0.689	0.480	.011	15	view →
CESC	DFS	Tertile	III,IV	0.190	0.691	.013	14	view →
DLBC	DFS	Tertile	All	0.502	1.000	.024	13	view →
SKCM	OS	Tertile	All	0.849	0.752	.012	12	view →
LIHC	DFS	Tertile	III,IV	0.572	0.242	.035	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

ERVV-1–BRCA (OS)

Open the BRCA breakdown →