ERVV-1

Across TCGA patient cohorts, ERVV-1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVV-1-associated genes across cancer lineages are 14-3-3_beta, eEF2, and eIF4G. Each is linked with ERVV-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVV-1-to-partner and partner-to-ERVV-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ERVV-1-low versus ERVV-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVV-1→partner) and Y-score (partner→ERVV-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.111	-2.432	.006	.018	3	1
UCEC	eEF2 →	+0.453	+1.906	.001	.016	3	1
UCEC	eIF4G →	+0.258	+1.906	.038	.016	3	1
UCEC	A-Raf_pS299 →	-0.178	-2.415	<.001	.003	3	1
UCEC	ERK2 →	+0.238	+1.906	.002	.016	3	1
UCEC	ACC1 →	+0.322	+3.013	.027	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

14-3-3_beta by ERVV-1 expression — UCEC

Explore this box plot interactively →