ERVH48-1

Across TCGA patient cohorts, ERVH48-1 mutation is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVH48-1-associated genes across cancer lineages are CHURC1-FNTB, ZIC5, and SNORD3A. Each is linked with ERVH48-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVH48-1-to-partner and partner-to-ERVH48-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHURC1-FNTB grouped by ERVH48-1-low versus ERVH48-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVH48-1→partner) and Y-score (partner→ERVH48-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHURC1-FNTB →	+0.090	+3.958	<.001	.001	3	1
UCEC	ZIC5 →	+2.720	+3.600	<.001	.004	3	1
UCEC	SNORD3A →	+0.471	+3.205	<.001	.003	3	1
UCEC	MIR4644 →	+0.868	+2.987	.001	.006	3	1
UCEC	NPM1P1 →	+0.463	+3.909	<.001	.001	3	1
UCEC	HSPE1-MOB4 →	+0.252	+4.021	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

CHURC1-FNTB by ERVH48-1 expression — UCEC

Explore this box plot interactively →