ERVH48-1

Across TCGA pan-cancer cohorts, ERVH48-1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ERVH48-1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ERVH48-1 RNA is repressed in tumor relative to normal tissue. In most cancer types ERVH48-1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, LUAD, and CHOL are the cancer types where ERVH48-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERVH48-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.230	<.001	6	view →
LUAD	All	All	+0.540	.005	3	view →
CHOL	All	II,III,IV	+0.194	.025	3	view →
COAD	All	II,III,IV	+0.066	.009	3	view →
PRAD	All	All	+2.266	<.001	2	view →
READ	All	All	+0.187	.017	2	view →
KIRP	All	All	−0.075	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ERVH48-1–THCA

Open the THCA breakdown →