ERVH48-1

Across TCGA pan-cancer cohorts, ERVH48-1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ERVH48-1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ERVH48-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERVH48-1 expression acts as an unfavorable survival marker, although some lineages such as LGG and LIHC show a favorable association.

UVM, LGG, and LIHC are the cancer types where ERVH48-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.269	0.754	.004	32	view →
LGG	OS	Median	All	0.497	0.388	.001	21	view →
LIHC	OS	Tertile	All	0.820	0.574	.004	19	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	18	view →
COAD	OS	Tertile	III,IV	0.256	0.624	.001	16	view →
THYM	OS	Tertile	All	0.941	0.672	.007	15	view →
PCPG	OS	Median	All	0.933	1.000	.014	12	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	11	view →
UCEC	OS	Quartile	III,IV	0.793	0.497	.015	10	view →
SARC	OS	Tertile	All	0.871	0.802	.020	9	view →
PAAD	DFS	Median	All	0.356	0.209	.010	7	view →
THCA	DFS	Tertile	II,III,IV	0.417	0.883	.029	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ERVH48-1–UVM (DFS)

Open the UVM breakdown →