ERP44

Across TCGA patient cohorts, ERP44 mutation is significantly associated with the RNA expression of many other genes, with 3,945 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERP44-associated genes across cancer lineages are UGT1A5, RNA5SP410, and RNA5SP422. Each is linked with ERP44 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERP44-to-partner and partner-to-ERP44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UGT1A5 grouped by ERP44-low versus ERP44-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERP44→partner) and Y-score (partner→ERP44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	UGT1A5 →	+0.069	+4.649	<.001	.001	3	2
UCEC	RNA5SP410 →	+0.483	+1.566	<.001	.007	3	2
UCEC	RNA5SP422 →	+0.598	+1.671	<.001	.003	3	2
CESC	RNA5SP421 →	+0.203	+5.252	<.001	.002	3	2
HNSC	RNU6-724P →	+0.364	+5.435	<.001	.005	3	2
UCEC	SNX3P1Y →	+0.058	+3.671	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,945 associations by consensus.

UGT1A5 by ERP44 expression — CESC

Explore this box plot interactively →