ERP44

Across TCGA pan-cancer cohorts, ERP44 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ERP44’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ERP44 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ERP44 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where ERP44 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERP44 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.933	<.001	12	view →
THCA	Male	III,IV	−0.637	<.001	9	view →
LIHC	Female	II,III,IV	+0.566	<.001	8	view →
STAD	All	All	+0.521	<.001	8	view →
KIRC	All	All	+0.264	<.001	6	view →
ESCA	All	All	+0.737	.001	4	view →
BLCA	All	III,IV	+0.395	.008	4	view →
KICH	All	All	−0.590	.003	3	view →
CHOL	All	II,III,IV	+1.104	.018	2	view →
PRAD	All	All	+0.267	.002	2	view →
KIRP	Male	II,III,IV	+0.330	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ERP44–HNSC

Open the HNSC breakdown →