ERN1

Across TCGA cell cohorts, ERN1 mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERN1-associated genes across cancer lineages are C18orf63, GPR148, and OR7E24. Each is linked with ERN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERN1-to-partner and partner-to-ERN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf63 grouped by ERN1-low versus ERN1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERN1→partner) and Y-score (partner→ERN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	2
OVARY	GPR148 →	+0.039	+3.417	<.001	.001	3	2
SOFT_TISSUE	OR7E24 →	+0.022	+4.369	<.001	.008	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.024	+4.369	<.001	.008	3	1
SOFT_TISSUE	FGF4 →	+0.038	+4.417	<.001	.004	3	1
BLOOD_Myeloma	NEUROD4 →	+0.006	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

C18orf63 by ERN1 expression — BLOOD_Lymphoma

Explore this box plot interactively →