ERICH3

Across TCGA patient cohorts, ERICH3 mutation is significantly associated with the total protein of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERICH3-associated genes across cancer lineages are GAPDH, Cyclin-B1, and p70-S6K. Each is linked with ERICH3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ERICH3-to-partner and partner-to-ERICH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ERICH3-low versus ERICH3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERICH3→partner) and Y-score (partner→ERICH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GAPDH →	+0.408	+1.584	.008	.013	3	4
UCEC	Cyclin-B1 →	+0.599	+2.584	<.001	<.001	3	4
LUAD	p70-S6K →	+0.181	+1.201	.004	.026	3	4
COAD	c-Kit →	-0.676	-2.321	.007	.033	3	4
UCEC	JNK_pT183_Y185 →	-0.124	-1.263	.005	.016	3	4
LUAD	FoxM1 →	+0.208	+1.733	.006	.022	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

GAPDH by ERICH3 expression — LUSC

Explore this box plot interactively →