ERICH3

Across TCGA pan-cancer cohorts, ERICH3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ERICH3 data layer compared with 9 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ERICH3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ERICH3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and MESO show a favorable association.

BRCA, MESO, and UCEC are the cancer types where ERICH3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.949	0.896	<.001	118	view →
MESO	OS	Tertile	All	0.507	0.260	<.001	86	view →
UCEC	OS	Median	All	0.781	0.583	<.001	82	view →
SCLC	OS	Median	III,IV	0.819	0.402	<.001	68	view →
SKCM	OS	Quartile	All	0.874	0.685	<.001	63	view →
HNSC	DFS	Tertile	All	0.787	0.653	.004	58	view →
KIRP	DFS	Quartile	II,III,IV	0.491	0.946	<.001	52	view →
PAAD	DFS	Quartile	All	0.430	0.163	<.001	41	view →
LGG	OS	Tertile	All	0.744	0.882	<.001	39	view →
LAML	DFS	Tertile	All	0.247	0.492	.012	38	view →
STAD	OS	Quartile	All	0.461	0.686	.003	33	view →
OV	OS	Tertile	IV	0.431	0.731	<.001	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ERICH3–BRCA (OS)

Open the BRCA breakdown →