ERICH3

Across TCGA pan-cancer cohorts, ERICH3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ERICH3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ERICH3 RNA is repressed in tumor relative to normal tissue. In most cancer types ERICH3 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and COAD are the cancer types where ERICH3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERICH3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−1.490	<.001	9	view →
LUSC	Female	II,III,IV	−2.108	<.001	8	view →
COAD	Female	All	−0.104	<.001	8	view →
READ	All	All	−0.193	.005	3	view →
BLCA	Female	IV	−0.059	.015	3	view →
STAD	Male	IV	−0.205	.036	2	view →
LIHC	Male	III,IV	−0.092	.023	2	view →
KIRC	All	All	+0.076	.003	2	view →
BRCA	Female	II,III,IV	−0.316	.048	1	view →
CHOL	Male	All	−0.139	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ERICH3–LUAD

Open the LUAD breakdown →