ERI3

Across TCGA cell cohorts, ERI3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ERI3-associated genes across cancer lineages are GPR142, LHX5, and PTH. Each is linked with ERI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERI3-to-partner and partner-to-ERI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR142 grouped by ERI3-low versus ERI3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERI3→partner) and Y-score (partner→ERI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GPR142 →	+0.046	+4.191	.002	.007	3	1
BLOOD_Lymphoma	LHX5 →	+0.029	+4.350	<.001	.005	3	1
LUNG_NSCLC_LUAD	PTH →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	C10orf71 →	+0.029	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.052	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GPR142 by ERI3 expression — BLOOD_Lymphoma

Explore this box plot interactively →