ERI3

Across TCGA pan-cancer cohorts, ERI3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ERI3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ERI3 RNA is repressed in tumor relative to normal tissue. In most cancer types ERI3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, COAD, and HNSC are the cancer types where ERI3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERI3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.567	<.001	10	view →
COAD	Female	All	+0.812	<.001	10	view →
HNSC	Male	III,IV	+0.699	<.001	10	view →
LIHC	Female	II,III,IV	+1.233	<.001	9	view →
THCA	Male	III,IV	−0.614	<.001	9	view →
LUSC	Female	All	+0.988	<.001	8	view →
BLCA	All	All	+0.666	<.001	8	view →
LUAD	Male	All	+0.519	<.001	7	view →
BRCA	All	III,IV	+0.462	<.001	6	view →
CHOL	All	All	+1.884	<.001	5	view →
STAD	Male	II,III,IV	+0.764	<.001	5	view →
UCEC	All	II,III,IV	+0.424	.025	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ERI3–KICH

Open the KICH breakdown →